effect of melatonin on cardiac injury after primary percutaneous coronary intervention: a randomized controlled trial

Authors

padideh ghaeli tehran university of medical sciences

shaghayegh vejdani tehran university of medical sciences

atefeh ariamanesh tehran university of medical sciences

azita hajhossein talasaz department of clinical pharmacy, faculty of pharmacy, tehran university of medical sciences

abstract

several studies have reported that the antioxidant properties of melatonin can provide cardiac protection through scavenging of free radicals. this study sought to investigate the efficacy of melatonin on cardiac biomarkers, myocardial-specific protein high sensitive troponin-t (hs-tnt) and creatine kinase-mb (ck-mb), in patients with st-segment elevation myocardial infarction (stemi) undergoing primary percutaneous coronary intervention (ppci). in this randomized clinical trial, a total of 40 patients with stemi planned to undergo ppci were randomly assigned to two groups of receiving melatonin plus standard treatment [n=20] and control group, receiving only standard therapy [n=20]. the following parameters including hstnt and ck-mb were assessed preoperatively (baseline) and at six hours after procedure. melatonin could significantly reduce the level of ck-mb (118.2 ± 21.09 iu/l in the treated group versus 198.24 ± 20.94 iu/l in the control group; p value = 0.01). however, there was no difference in the mean hs-tnt level between two groups (2491 ± 664 μg/l vs. 2801 ± 620 μg/l; p value = 0.73). our results revealed that melatonin can be considered as a safe adjunctive medication to the standard regimen after ppci for the aim of decreasing cardiovascular events. meanwhile, this was a pilot study with a small number of patients and further studies are needed to confirm the beneficial effect of melatonin in patients with stemi.

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

Effect of Melatonin on Cardiac Injury after Primary Percutaneous Coronary Intervention: a Randomized Controlled Trial

Several studies have reported that the antioxidant properties of melatonin can provide cardiac protection through scavenging of free radicals. This study sought to investigate the efficacy of melatonin on cardiac biomarkers, myocardial-specific protein high sensitive troponin-T (hs-TnT) and creatine kinase-MB (CK-MB), in patients with ST-segment elevation myocardial infarction (STEMI) undergoin...

full text

Effect of Melatonin on Cardiac Injury after Primary Percutaneous Coronary Intervention: a Randomized Controlled Trial

Several studies have reported that the antioxidant properties of melatonin can provide cardiac protection through scavenging of free radicals. This study sought to investigate the efficacy of melatonin on cardiac biomarkers, myocardial-specific protein high sensitive troponin-T (hs-TnT) and creatine kinase-MB (CK-MB), in patients with ST-segment elevation myocardial infarction (STEMI) undergoin...

full text

Effect of Melatonin on Cardiac Injury after Primary Percutaneous Coronary Intervention: a Randomized Controlled Trial

Several studies have reported that the antioxidant properties of melatonin can provide cardiac protection through scavenging of free radicals. This study sought to investigate the efficacy of melatonin on cardiac biomarkers, myocardial-specific protein high sensitive troponin-T (hs-TnT) and creatine kinase-MB (CK-MB), in patients with ST-segment elevation myocardial infarction (STEMI) undergoin...

full text

A Randomized Double Blind Placebo Controlled Trial Examining the Effects of Pentoxifylline on Contrast Induced Nephropathy Reduction after Percutaneous Coronary Intervention in High Risk Candidates

Contrast-induced nephropathy (CIN) (known as contrast-induced acute kidney injury) occurs as a result of acute worsening of renal function following a procedure with administration of iodine contrasts agent and remains a substantial concern in clinical practices. The purpose of this study is to investigate the preventive effect of Pentoxifylline supplementation on reduction of CIN occurrence af...

full text

A Randomized Double Blind Placebo Controlled Trial Examining the Effects of Pentoxifylline on Contrast Induced Nephropathy Reduction after Percutaneous Coronary Intervention in High Risk Candidates

Contrast-induced nephropathy (CIN) (known as contrast-induced acute kidney injury) occurs as a result of acute worsening of renal function following a procedure with administration of iodine contrasts agent and remains a substantial concern in clinical practices. The purpose of this study is to investigate the preventive effect of Pentoxifylline supplementation on reduction of CIN occurrence af...

full text

Fluvastatin for prevention of cardiac events following successful first percutaneous coronary intervention: a randomized controlled trial.

CONTEXT Percutaneous coronary intervention (PCI) is associated with excellent short-term improvements in ischemic symptoms, yet only three fifths of PCI patients at 5 years and one third of patients at 10 years remain free of major adverse cardiac events (MACE). OBJECTIVE To determine whether treatment with fluvastatin reduces MACE in patients who have undergone PCI. DESIGN AND SETTING Rand...

full text

My Resources

Save resource for easier access later


Journal title:
iranian journal of pharmaceutical research

جلد ۱۴، شماره ۳، صفحات ۸۵۱-۸۵۵

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023